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Mortier L1, Vijgen S1, Declercq P1, Mewis A1 1 Jessa ziekenhuis, Hasselt, Belgium Aims: Cyclosporine and tacrolimus are powerful immunosuppressant drugs that are widely used therapeutically to prevent rejection after transplantations, including stem cell transplantations.

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Ismael SI 1 Department of Pharmacology, Faculty of Medicine, The University of Jordan, Amman, Jordan; 2Departments of Biochemistry and Physiology, Amman, Jordan Aims: Thiopurine S-methyltransferase (TPMT) enzyme, is responsible for inactivation of thiopurine drugs which are commonly used in leukemia, organ transplantation and autoimmune diseases.

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Tada H, Satoh S, Iinuma M, Shimoda N, Murakami M, Hayase Y, Kato T, and Suzuki T ( 2003) Chronopharmacokinetics of tacrolimus in kidney transplant recipients: occurrence of acute rejection.

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New data presented today at The International Liver Congress 2015, supports the use of sofosbuvir (SOF)- and daclatasvir (DCV)-based regimens in patients with recurrence of the hepatitis C virus (HCV) following liver transplantation (LT).

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Dear health care provider letter regarding increased risk of hepatic artery thrombosis, graft loss, and death associated with use of sirolimus (Rapamune ) in combination with other immunosuppressants such as cyclosporine or tacrolimus in de novo liver transplant recipients.

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Tacrolimus, a more recently introduced calcineurin inhibitor, is reportedly more effective than cyclosporine at improving allograft survival and preventing acute rejection at 1 year.

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