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CD25 blockade in kidney transplant patients randomized to standard-dose or high-dose basiliximab with cyclosporine, or high-dose basiliximab in a calcineurin inhibitor-free regimen.
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Higher levels are often sought immediately after transplant, but as organ function stabilizes at about 4 weeks from transplant, doses are generally reduced in stable patients for most solid organ transplants.
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Mortier L1, Vijgen S1, Declercq P1, Mewis A1 1 Jessa ziekenhuis, Hasselt, Belgium Aims: Cyclosporine and tacrolimus are powerful immunosuppressant drugs that are widely used therapeutically to prevent rejection after transplantations, including stem cell transplantations.
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Ismael SI 1 Department of Pharmacology, Faculty of Medicine, The University of Jordan, Amman, Jordan; 2Departments of Biochemistry and Physiology, Amman, Jordan Aims: Thiopurine S-methyltransferase (TPMT) enzyme, is responsible for inactivation of thiopurine drugs which are commonly used in leukemia, organ transplantation and autoimmune diseases.
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Tada H, Satoh S, Iinuma M, Shimoda N, Murakami M, Hayase Y, Kato T, and Suzuki T ( 2003) Chronopharmacokinetics of tacrolimus in kidney transplant recipients: occurrence of acute rejection.
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New data presented today at The International Liver Congress 2015, supports the use of sofosbuvir (SOF)- and daclatasvir (DCV)-based regimens in patients with recurrence of the hepatitis C virus (HCV) following liver transplantation (LT).
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Motzer RJ, Escudier B, Mcdermott DF et al. Nivolumab versus Everolimus in Advanced RenalCell Carcinoma.
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Dear health care provider letter regarding increased risk of hepatic artery thrombosis, graft loss, and death associated with use of sirolimus (Rapamune ) in combination with other immunosuppressants such as cyclosporine or tacrolimus in de novo liver transplant recipients.
Treatment of atopic eyelid disease using topical tacrolimus following corticosteroid discontinuation in a patient with open-angle glaucoma.
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Plasmapheresis and rituximab were initially used for treatment of recurrent SRNS after transplantation; these are now under consideration as rescue therapies for refractory SRNS.
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Tacrolimus, a more recently introduced calcineurin inhibitor, is reportedly more effective than cyclosporine at improving allograft survival and preventing acute rejection at 1 year.
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